Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Some viral outbreaks have plagued the world since antiquity, including the most recent
COVID-19 pandemic. The continuous spread and emergence of new viral diseases have …

Polyhydroquinoline (PHQ) are the unsymmetrical Hantzsch derivatives of 1, 4-
dihydropyridines with several biological applications. In this work, twenty-five (3–27) new …

The chalcone and bis-chalcone derivatives have been synthesized under sonication
conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20 …

A new series of heterocyclic molecules bearing sulfonamide linkage has been synthesized
and screened for antibacterial activity. During antibacterial screening using broath dilution …

A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …

Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired
immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since …

Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …

A novel quinoline derivative,(E)-N-phenyl-4-((quinoli-4-ylmethylene) amino) aniline (PQYA),
was synthesized using a previously reported approach with 80% yield. Single X-ray …

Microbial infections remain serious diseases and their frequency continues to increase. It is
therefore essential to find effective therapeutic agents with the least side effects. Chalcones …