Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Altered expression and function of the transcription factor cyclic AMP response-binding
protein (CREB) has been identified to play an important role in cancer and is associated with …

J. Neurochem.(2011) 116, 1–9. Abstract Since its initial characterization over 20 years ago,
there has been intense and unwavering interest in understanding the role of the …

We studied a mouse model of the haploinsufficiency form of Rubinstein-Taybi syndrome
(RTS), an inheritable disorder caused by mutations in the gene encoding the CREB binding …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

Drug addiction is a brain disorder caused by the repetitive use of various chemicals which
alter normal functioning of the central nervous system with consequent behavioral …

Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …

Lysine acetylation has been shown to occur in many protein targets, including core histones,
about 40 transcription factors and over 30 other proteins. This modification is reversible in …

The transcription factor cyclic AMP–response element binding protein (CREB) is a key
regulator of many neuronal processes, including brain development, circadian rhythm and …