Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins
Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …
Glutathione peroxidases
R Brigelius-Flohé, M Maiorino - … et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Glutathione peroxidase family–an evolutionary overview
Glutathione peroxidases (EC 1.11. 1.9 and EC 1.11. 1.12) catalyze the reduction of H2O2 or
organic hydroperoxides to water or corresponding alcohols using reduced glutathione …
organic hydroperoxides to water or corresponding alcohols using reduced glutathione …
Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation
VD Nguyen, MJ Saaranen, AR Karala, AK Lappi… - Journal of molecular …, 2011 - Elsevier
Disulfide bond formation in the endoplasmic reticulum by the sulfhydryl oxidase Ero1 family
is thought to be accompanied by the concomitant formation of hydrogen peroxide. Since …
is thought to be accompanied by the concomitant formation of hydrogen peroxide. Since …
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets
Genetic and epigenetic mechanisms may interact and together affect biological processes
and disease development. However, most previous studies have investigated genetic and …
and disease development. However, most previous studies have investigated genetic and …
Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily
Glutathione peroxidase (GPx) is a widespread protein superfamily found in many organisms
throughout all kingdoms of life. Although it was initially thought to use only glutathione as …
throughout all kingdoms of life. Although it was initially thought to use only glutathione as …
Seleno‐independent glutathione peroxidases: More than simple antioxidant scavengers
S Herbette, P Roeckel‐Drevet, JR Drevet - The FEBS journal, 2007 - Wiley Online Library
Glutathione peroxidases (GPXs, EC 1.11. 1.9) were first discovered in mammals as key
enzymes involved in scavenging of activated oxygen species (AOS). Their efficient …
enzymes involved in scavenging of activated oxygen species (AOS). Their efficient …
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
P Stafford, MG Abdelwahab, DY Kim, MC Preul… - Nutrition & …, 2010 - Springer
Background Malignant brain tumors affect people of all ages and are the second leading
cause of cancer deaths in children. While current treatments are effective and improve …
cause of cancer deaths in children. While current treatments are effective and improve …
Human selenoproteins at a glance
S Gromer, JK Eubel, BL Lee, J Jacob - Cellular and Molecular Life …, 2005 - Springer
The public perception of selenium has changed significantly over the last decades.
Originally mainly known for its high toxicity, it was later recognized as an essential trace …
Originally mainly known for its high toxicity, it was later recognized as an essential trace …