[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …
cognitive impairment, and dementia. Here, we review the cellular and molecular …
Protease-activated receptors in health and disease
CJ Peach, LE Edgington-Mitchell… - Physiological …, 2023 - journals.physiology.org
Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …
protease-activated receptors (PARs). The four known PARs are members of the large family …
Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
Activated protein C: biased for translation
JH Griffin, BV Zlokovic… - Blood, The Journal of the …, 2015 - ashpublications.org
The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …
Final results of the RHAPSODY trial: a multi‐center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A‐APC, a …
Objective Agonism of protease‐activated receptor (PAR) 1 by activated protein C (APC)
provides neuro‐and vasculoprotection in experimental neuroinjury models. The pleiotropic …
provides neuro‐and vasculoprotection in experimental neuroinjury models. The pleiotropic …
Proteinase-activated receptors (PARs)–focus on receptor-receptor-interactions and their physiological and pathophysiological impact
F Gieseler, H Ungefroren, U Settmacher… - Cell Communication and …, 2013 - Springer
Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …
Activated protein C, protease activated receptor 1, and neuroprotection
JH Griffin, BV Zlokovic… - Blood, The Journal of the …, 2018 - ashpublications.org
Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
The Zika virus capsid disrupts corticogenesis by suppressing dicer activity and miRNA biogenesis
J Zeng, S Dong, Z Luo, X Xie, B Fu, P Li, C Liu, X Yang… - Cell Stem Cell, 2020 - cell.com
Zika virus (ZIKV) causes microcephaly and disrupts neurogenesis. Dicer-mediated miRNA
biogenesis is required for embryonic brain development and has been suggested to be …
biogenesis is required for embryonic brain development and has been suggested to be …
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Background PICALM is one of the most significant susceptibility factors for Alzheimer's
disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium …
disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium …
3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice
Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling
activities mediated by the activation of protease-activated receptor 1 (F2R, also known as …
activities mediated by the activation of protease-activated receptor 1 (F2R, also known as …