Design, synthesis and biological evaluation of 2-quinolyl-1, 3-tropolone derivatives as new anti-cancer agents

EA Gusakov, IA Topchu, AM Mazitova, IV Dorogan… - RSC …, 2021 - pubs.rsc.org
Tropolones are promising organic compounds that can have important biologic effects. We
developed a series of new 2-quinolyl-1, 3-tropolones derivatives that were prepared by the …

Synthesis of 2‐Alkenyl‐4H‐3,1‐Benzoxazin‐4‐Ones through HFIP‐Mediated Decarboxylative [4+2]‐Annulation of Isatoic Anhydrides with Cyclopropenones under …

M Yang, J Wang, W Lv, D Ba… - Advanced Synthesis & …, 2021 - Wiley Online Library
We herein describes an HFIP‐mediated [4+ 2]‐cycloaddition reaction from simple and easily
available isatoic anhydrides and cyclopropenones under silver catalysis. This transformation …

Construction of Difluorinated Cycloheptadienones via Substrate‐Controlled Regioselective Conjugate Addition of Difluoroenoxysilanes to Tropones and Their …

XY Wang, YZ Guo, S Shi, S Li, JS Yu… - Advanced Synthesis …, 2024 - Wiley Online Library
The substrate‐controlled regioselective conjugate addition (1, 8‐and 1, 4‐addition) of
tropones with difluoroenoxysilanes is reported, which offered an approach for the selective …

Synthesis, molecular structure and biological activity of novel bis-1, 3-tropolones based on 4-chloro-2, 7-dimethyl-1, 8-naphthyridine

EA Gusakov, YA Sayapin, EV Vetrova… - Mendeleev …, 2024 - Elsevier
The acid-catalyzed reaction of 4-chloro-2, 7-dimethyl-1, 8-naphthyridine with 4, 6-di-tert-
butyl-3-nitro-1, 2-benzoquinone leads to new bis-1, 3-tropolones. The crystal structures of …

DDQ-mediated oxidative coupling reaction of N, N-dimethyl enaminones with cycloheptatriene

D Cheng, C Yu, Y Pu, X Xu - Tetrahedron Letters, 2022 - Elsevier
Abstract An efficient 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ)-mediated
oxidative coupling reaction of N, N-dimethyl enaminones with cycloheptatriene is …

[HTML][HTML] Reaction of quinaldine with 4, 6-di (tert-butyl)-3-nitro-1, 2-benzoquinone. Dependence of the outcome on the reaction conditions and a deeper insight into the …

TA Krasnikova, YA Sayapin, IO Tupaeva, EA Gusakov… - Heliyon, 2023 - cell.com
Abstract Condensation of quinaldine with 4, 6-di (tert-butyl)-3-nitro-1, 2-benzoquinone
results in the formation of 5, 7-di (tert-butyl)-2-(quinoline-2-yl)-1, 3-tropolone, 5, 7-di (tert …

Structure of 2-(benzoxazole-2-Yl)- 5,7-di(tert-butyl)-4-nitro-1,3-tropolone

VV Tkachev, YA Sayapin, IO Tupaeva… - Journal of Structural …, 2018 - Springer
The reaction of 2-methylbenzoxazole with 4, 6-di (tert-butyl)-3-nitro-1, 2-benzoquinone
yields 2-(benzoxazole-2-yl)-5, 7-di (tert-butyl)-4-nitro-1, 3-tropolone. The structure of 2 …

Synthesis and Molecular Structure of 3-[N-Acetyl(3,5-dimethylphenyl)amino]-5,7-di(tert-butyl)-2-{5,8-dimethyl-4-[(3,5-dimethylphenyl)amino]quinolin-2-yl}tropone

VV Tkachev, YA Sayapin, EA Gusakov… - Russian Journal of …, 2022 - Springer
Abstract Acylation of 5, 7-di (tert-butyl)-2-{5, 8-dimethyl-4-[(3, 5-dimethylphenyl) amino]
quinolin-2-yl}-3-[(3, 5-dimethylphenyl) amino] tropone leads to 3-[aryl (acetyl) amino] …

Synthesis, Structure, Ionochromic and Cytotoxic Properties of New 2-(Indolin-2-Yl)-1, 3-Tropolones

YA Sayapin, EA Gusakov, IO Tupaeva… - Available at SSRN … - papers.ssrn.com
The acid-catalyzed reaction of benzo [e (g)] derivatives of 2, 3, 3-trimethylindolines with o-
chloranil leads to the new 2-(benzo [e (g)] indolin-2-yl)-5, 6, 7-trichloro-1, 3-tropolones and 2 …

Synthesis and structure of 4,6-di(tert-butyl)-2-(4-chloro-7,8-dimethylquinolin-2-yl)-7-(piperidin-1-ylmethyl)-1,3-tropolone

VV Tkachev, YA Sayapin, IV Dorogan… - Russian Chemical …, 2017 - Springer
Abstract The reaction of 4-chloro-2, 7, 8-trimethylquinoline with 4, 6-di (tert-butyl)-3-
(piperidin-1-ylmethyl)-1, 2-benzoquinone, which was prepared by the in situ oxidation of 4, 6 …