Comprehensive review in current developments of imidazole‐based medicinal chemistry

L Zhang, XM Peng, GLV Damu… - Medicinal research …, 2014 - Wiley Online Library
Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Current developments of coumarin compounds in medicinal chemistry

XM Peng, G LV Damu, C He Zhou - Current pharmaceutical …, 2013 - benthamdirect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Comprehensive insights into medicinal research on imidazole-based supramolecular complexes

SR Li, YM Tan, L Zhang, CH Zhou - Pharmaceutics, 2023 - mdpi.com
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …

Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

GF Zha, HD Preetham, S Rangappa, KSS Kumar… - Bioorganic …, 2021 - Elsevier
Small molecule based inhibitors development is a growing field in medicinal chemistry. In
recent years, different heterocyclic derivatives have been designed to counter the infections …

Recent developments in azole compounds as antibacterial and antifungal agents

XM Peng, GX Cai, CH Zhou - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation

HB Liu, WW Gao, VKR Tangadanchu, CH Zhou… - European journal of …, 2018 - Elsevier
A series of novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents were
designed, synthesized and characterized by IR, NMR and HRMS spectra. The biological …

Novel 3-aminothiazolquinolones: design, synthesis, bioactive evaluation, SARs, and preliminary antibacterial mechanism

SF Cui, D Addla, CH Zhou - Journal of Medicinal Chemistry, 2016 - ACS Publications
A series of novel 3-aminothiazolquinolones as analogues of quinolone antibacterial agents
were designed and synthesized in an effort to circumvent quinolone resistance. Among …

Recent advances and therapeutic journey of coumarins: current status and perspectives

KP Barot, SV Jain, L Kremer, S Singh… - Medicinal Chemistry …, 2015 - Springer
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different
coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants …