To Erase or not to erase: non-canonical catalytic functions and non-catalytic functions of members of histone lysine demethylase families
E Di Nisio, V Manzini, V Licursi, R Negri - International Journal of …, 2024 - mdpi.com
Histone lysine demethylases (KDMs) play an essential role in biological processes such as
transcription regulation, RNA maturation, transposable element control, and genome …
transcription regulation, RNA maturation, transposable element control, and genome …
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
L Tao, Y Zhou, X Pan, Y Luo, J Qiu, X Zhou… - Nature …, 2023 - nature.com
Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer
(OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in …
(OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in …
Promising therapy for neuroendocrine prostate cancer: current status and future directions
X Fei, JW Xue, J Wu, CY Yang… - … Advances in Medical …, 2024 - journals.sagepub.com
Neuroendocrine prostate cancer (NEPC) is a highly aggressive variant of castration-
resistant prostate cancer. It is characterized by low or no expression of the androgen …
resistant prostate cancer. It is characterized by low or no expression of the androgen …
Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targets
J Jiang, D Han, J Wang, W Wen, R Zhang, W Qin - MedComm, 2024 - Wiley Online Library
Neuroendocrine transdifferentiation (NEtD), also commonly referred to as lineage plasticity,
emerges as an acquired resistance mechanism to molecular targeted therapies in multiple …
emerges as an acquired resistance mechanism to molecular targeted therapies in multiple …
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models
S Jasmine, A Mandl, TEG Krueger, SL Dalrymple… - The …, 2024 - Wiley Online Library
Introduction Lysine‐specific demethylase 1 (LSD1) is emerging as a critical mediator of
tumor progression in metastatic castration‐resistant prostate cancer (mCRPC) …
tumor progression in metastatic castration‐resistant prostate cancer (mCRPC) …
Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer
I Zamora, MR Freeman, IJ Encío, M Rotinen - International Journal of …, 2023 - mdpi.com
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer
(PC) that commonly emerges through a transdifferentiation process from prostate …
(PC) that commonly emerges through a transdifferentiation process from prostate …
Prostate cancer lineage plasticity is associated with an altered MYC/MAX cistrome through super-enhancer remodeling
M Kobelev - 2024 - open.library.ubc.ca
Next-generation androgen receptor (AR) pathway inhibitors (ARPIs) have been very
successful at prolonging the life of men with prostate cancer. However, all patients will …
successful at prolonging the life of men with prostate cancer. However, all patients will …
LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer
CA Ladaika, AH Ghobashi, WC Boulton… - Cancer …, 2024 - aacrjournals.org
Neuroendocrine cells have been implicated in therapeutic resistance and worse overall
survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for …
survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for …
[引用][C] Targeting key players of neuroendocrine differentiation in prostate cancer
I Zamora Álvarez, MR Freeman, I Encío Martínez… - International Journal of …, 2023 - MDPI