Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Inflammasome activation leads to caspase-1 activation, which causes the maturation and
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise
roles in intestinal inflammation remain unknown. Here we show that activation of mast cells …

Innate immune responses act as first line defences upon exposure to potentially noxious
stimuli. The innate immune system has evolved numerous intracellular and extracellular …

Purine nucleotides are well established as extracellular signaling molecules. P2X7
receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their …