Currently, around 11 million people are living with a tumour that contains an inactivating
mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours …

Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …

Over the years, p53 has been shown to sit at the centre of an increasingly complex web of
incoming stress signals and outgoing effector pathways. The number and diversity of stress …

The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor
suppressor protein p53—a cellular process initiated by MDM2 and/or MDMX binding to the …

The growing consumer awareness towards healthy and safe food has reformed food
processing strategies. Nowadays, food processors are aiming at natural, effective, safe, and …

Abstract p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target
because it can be functionally activated to eradicate tumors. The gene encoding p53 protein …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Over the course of three decades of study, the deubiquitinase Herpesvirus associated
Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually …