Protocell effects on RNA folding, function, and evolution
Conspectus Creating a living system from nonliving matter is a great challenge in chemistry
and biophysics. The early history of life can provide inspiration from the idea of the prebiotic …
and biophysics. The early history of life can provide inspiration from the idea of the prebiotic …
A Peptide-Based Oscillator
Living organisms are replete with rhythmic and oscillatory behavior at all levels, to the extent
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …
Enhanced condensation kinetics in aqueous microdroplets driven by coupled surface reactions and gas-phase partitioning
Although aqueous microdroplets have been shown to exhibit enhanced chemical reactivity
compared to bulk solutions, mechanisms for these enhancements are not completely …
compared to bulk solutions, mechanisms for these enhancements are not completely …
Evolution at the Origins of Life?
The role of evolutionary theory at the origin of life is an extensively debated topic. The origin
and early development of life is usually separated into a prebiotic phase and a protocellular …
and early development of life is usually separated into a prebiotic phase and a protocellular …
Design of multi-responsive and actuating microgels toward on-demand drug release
Multifunctional colloidal microgels that exhibit stimuli-responsive behaviour and excellent
biocompatibility have attracted particular attention for developing functional …
biocompatibility have attracted particular attention for developing functional …
Origin & influence of autocatalytic reaction networks at the advent of the RNA world
SA Zorc, RN Roy - RNA biology, 2024 - Taylor & Francis
Research on the origin of life investigates the transition from abiotic chemistry to the
emergence of biology, with the 'RNA world hypothesis' as the leading theory. RNA's dual …
emergence of biology, with the 'RNA world hypothesis' as the leading theory. RNA's dual …
Multistable protocells can aid the evolution of prebiotic autocatalytic sets
We present a simple mathematical model that captures the evolutionary capabilities of a
prebiotic compartment or protocell. In the model, the protocell contains an autocatalytic set …
prebiotic compartment or protocell. In the model, the protocell contains an autocatalytic set …
Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales
Integral feedback control strategies have proven effective in regulating protein expression in
unpredictable cellular environments. These strategies, grounded in model-based designs …
unpredictable cellular environments. These strategies, grounded in model-based designs …
From messy chemistry to ecology: autocatalysis and heritability in prebiotically plausible chemical systems
T Sokolskyi, BC Zuviria, S Gargulak, E Allen, D Baum - bioRxiv, 2024 - biorxiv.org
A key question in origins-of-life research, is whether heritability, and thus evolution, could
have preceded genes. While theoretical research has shown that out of equilibrium …
have preceded genes. While theoretical research has shown that out of equilibrium …
Combined Network and High Resolution Mass Spectrometry Analysis of the Formose Reaction Reveals Mechanisms for Emergent Behaviors
The formose reaction (FR) autocatalytically converts simple plausibly prebiotic feedstocks
into molecules of biological interest, including ribose. Autocatalysis is a hallmark of life, thus …
into molecules of biological interest, including ribose. Autocatalysis is a hallmark of life, thus …