Functional neurophysiological biomarkers of early-stage Alzheimer's disease: A perspective of network hyperexcitability in disease progression

S Tok, A Ahnaou… - Journal of Alzheimer's …, 2022 - content.iospress.com
Network hyperexcitability (NH) has recently been suggested as a potential
neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers …

AFM and FluidFM technologies: recent applications in molecular and cellular biology

MY Amarouch, J El Hilaly, D Mazouzi - Scanning, 2018 - Wiley Online Library
Atomic force microscopy (AFM) is a widely used imaging technique in material sciences.
After becoming a standard surface‐imaging tool, AFM has been proven to be useful in …

Erythromelalgia

PF Klein-Weigel, TS Volz, JG Richter - Vasa, 2018 - econtent.hogrefe.com
Erythromelalgia is a rare syndrome characterized by the intermittent or, less commonly, by
the permanent occurrence of extremely painful hyperperfused skin areas mainly located in …

Predicting changes to INa from missense mutations in human SCN5A

M Clerx, J Heijman, P Collins, PGA Volders - Scientific reports, 2018 - nature.com
Mutations in SCN5A can alter the cardiac sodium current I Na and increase the risk of
potentially lethal conditions such as Brugada and long-QT syndromes. The relation between …

Role of the Purkinje system in heritable arrhythmias

AAM Wilde, H Garan, PA Boyden - Heart Rhythm, 2019 - Elsevier
Much has been written about arrhythmias in structurally normal hearts. In this review, we
focus on rapid ventricular arrhythmias that occur in hearts having a pathogenic genetic …

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites

Y Wang, E Yang, MM Wells, V Bondarenko… - Journal of General …, 2018 - rupress.org
Voltage-gated sodium (NaV) channels are important targets of general anesthetics,
including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic …

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

G Wisedchaisri, TM Gamal El-Din, NM Powell… - Journal of General …, 2023 - rupress.org
Voltage-gated sodium channels in peripheral nerves conduct nociceptive signals from nerve
endings to the spinal cord. Mutations in voltage-gated sodium channel NaV1. 7 are …

[HTML][HTML] Application of TCM network pharmacology and experimental verification to explore the mechanism of kaempferol against epilepsy

J Zhao, X Qin, L Yang, H Guo, S Chen, K Tian… - Brain Research …, 2025 - Elsevier
Background Kaempferol (KF), the main active ingredient in identifying the authenticity of
safflower, has a variety of pharmacological activities and neuroprotective effects. However …

High-salt diet impairs the neurons plasticity and the neurotransmitters-related biological processes

X Du, L Yu, S Ling, J Xie, W Chen - Nutrients, 2021 - mdpi.com
Salt, commonly known as sodium chloride, is an important ingredient that the body requires
in relatively minute quantities. However, consuming too much salt can lead to high blood …

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin‐3‐Gallate on Cardiac Channelopathies

M Boukhabza, J El Hilaly, N Attiya… - … Methods in Medicine, 2016 - Wiley Online Library
Ion channels are transmembrane proteins that allow the passage of ions according to the
direction of their electrochemical gradients. Mutations in more than 30 genes encoding ion …