Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

The coordinated regulation of transcriptional networks underpins cellular identity and
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …

Muscle stem cells (MuSCs) reside in a specialized niche that ensures their regenerative
capacity. Although we know that innate immune cells infiltrate the niche in response to …

A balance between self-renewal and differentiation is critical for the regenerative capacity of
tissue-resident stem cells. In skeletal muscle, successful regeneration requires the …

Adult skeletal muscle harbours a population of muscle stem cells (MuSCs) that are required
for repair after tissue injury. In youth, MuSCs return to a reversible state of cell-cycle arrest …

Abstract Promoter-proximal RNA Pol II pausing is a critical step in transcriptional control. Pol
II pausing has been predominantly studied in tissue culture systems. While Pol II pausing …

Abstract T cell factor 1 (TCF1) is required for memory and stem-like CD8+ T cell functions.
How TCF1 partners with other transcription factors to regulate transcription remains unclear …

Adult stem cells persist in mammalian tissues by entering a state of reversible quiescence,
referred to as G0, which is associated with low levels of transcription. Using cultured …

骨骼肌再生过程中卫星细胞调控机制及其生态位信号的作用 Page 1 Chinese Journal of Tissue
Engineering Research|Vol 28|No.7|March 2024|1105 中国组织工程研究 Chinese Journal of …

RNA polymerase (Pol) II is highly regulated to ensure appropriate gene expression. Early
transcription elongation is associated with transient pausing of RNA Pol II in the promoter …