The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Cognitive dysfunction is a common adverse consequence of traumatic brain injury (TBI).
After brain injury, the brain and other organs trigger a series of complex metabolic changes …

INTRODUCTION Traumatic brain injury (TBI) is a leading cause of disability in children and
adults. TBI affects 69 million people worldwide yearly and can lead to cognitive dysfunction …

Neuromyelitis optica (NMO) is an autoimmune inflammatory disease of the central nervous
system (CNS) characterized by transverse myelitis and optic neuritis. The pathogenic serum …

Background Alzheimer's disease (AD) is a common cause of dementia. Serum complement
factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD …

Automated gait assessment tests are used in studies of disorders characterized by gait
impairment. CatWalk XT is one of the first commercially available automated systems for …

Activation of the complement system propagates neuroinflammation and brain damage early
and chronically after traumatic brain injury (TBI). The complement system is complex and …

Cognitive deficits are a common comorbidity with neurological disorders and normal aging.
Inflammation is associated with multiple diseases including classical neurodegenerative …

Traumatic Brain Injury (TBI) remains a leading cause of morbidity and mortality among all
ages; despite the advances, understanding pathophysiological responses after TBI is still …

Introduction Narcolepsy type 1 (NT1) is a rare, chronic and disabling neurological disease
causing excessive daytime sleepiness and cataplexy. NT1 is characterized pathologically by …