Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
VDAC, a multi-functional mitochondrial protein regulating cell life and death
V Shoshan-Barmatz, V De Pinto, M Zweckstetter… - Molecular aspects of …, 2010 - Elsevier
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …
include functions well beyond the generation of cellular energy. It is now recognized that …
VDAC, a multi-functional mitochondrial protein as a pharmacological target
V Shoshan-Barmatz, D Ben-Hail - Mitochondrion, 2012 - Elsevier
Regulation of mitochondrial physiology requires an efficient exchange of molecules
between mitochondria and the cytoplasm via the outer mitochondrial membrane (OMM). The …
between mitochondria and the cytoplasm via the outer mitochondrial membrane (OMM). The …
Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry
T Notter, JM Coughlin, A Sawa, U Meyer - Molecular psychiatry, 2018 - nature.com
A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …
The mitochondrial death pathway: a promising therapeutic target in diseases
• Introduction• Mitochondria and cell death• Mitochondrial outer membrane permeabilization
(MOMP): point of no return‐MOMP by BCL‐2 family proteins‐MOMP by permeability …
(MOMP): point of no return‐MOMP by BCL‐2 family proteins‐MOMP by permeability …
VDAC1: from structure to cancer therapy
V Shoshan-Barmatz, D Mizrachi - Frontiers in oncology, 2012 - frontiersin.org
Here, we review current evidence pointing to the function of VDAC1 in cell life and death,
and highlight these functions in relation to cancer. Found at the outer mitochondrial …
and highlight these functions in relation to cancer. Found at the outer mitochondrial …
The role of translocator protein TSPO in hallmarks of glioblastoma
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products
JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
The changing landscape in translocator protein (TSPO) function
V Selvaraj, DM Stocco - Trends in Endocrinology & Metabolism, 2015 - cell.com
Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor
(PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate …
(PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate …