[HTML][HTML] The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

H Zhang, L Fu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis

PJ Brooks, S Zakhari - Environmental and molecular …, 2014 - Wiley Online Library
The designation of acetaldehyde associated with the consumption of alcoholic beverages as
“carcinogenic to humans”(Group 1) by the International Agency for Research on Cancer …

Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium

A Mizumoto, S Ohashi, K Hirohashi… - International journal of …, 2017 - mdpi.com
Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA,
including DNA adducts, single-and/or double-strand breaks (DSBs), point mutations, sister …

Connecting the dots: investigating the link between environmental, genetic, and epigenetic influences in metabolomic alterations in oral squamous cell carcinoma

I Gupta, F Badrzadeh, Y Tsentalovich… - Journal of Experimental & …, 2024 - Springer
Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

Breast cancer prevention in premenopausal women: Role of the Mediterranean diet and its components

D Laudisio, L Barrea, G Muscogiuri… - Nutrition research …, 2020 - cambridge.org
Breast cancer (BC) is a growing public health concern in most developed and developing
countries. Since an increasing number of patients with BC are diagnosed before the …

Formation and repair of DNA-protein crosslink damage

NL Klages-Mundt, L Li - Science China Life Sciences, 2017 - Springer
DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms
of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a …

ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes

AYH Woo, L Jia - … Research-Fundamental and Molecular Mechanisms of …, 2024 - Elsevier
Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important
endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion …

Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA

K Housh, JS Jha, T Haldar, SBM Amin, T Islam… - DNA repair, 2021 - Elsevier
Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …

Prevalence and associated factors of baseline anemia among cervical cancer patients in Tikur Anbesa Specialized Hospital, Ethiopia

M Wassie, A Aemro, B Fentie - BMC Women's Health, 2021 - Springer
Background Almost one patient with cancer in two is anemic. About 40 to 64% of cervical
cancer patients are anemic at time of presentation. The rate of anemia increases with the …

Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: preclinical and clinical evidence

A Bishayee, Y Haskell, C Do, KS Siveen… - Critical Reviews in …, 2016 - Taylor & Francis
Epidemiological reports as well as experimental studies have demonstrated the significant
health benefits provided by regular berry consumption. Berries possess both prophylactic …