An overview of lipid droplets in cancer and cancer stem cells

L Tirinato, F Pagliari, T Limongi, M Marini… - Stem cells …, 2017 - Wiley Online Library
For decades, lipid droplets have been considered as the main cellular organelles involved
in the fat storage, because of their lipid composition. However, in recent years, some new …

Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications

W Wang, S Nag, X Zhang, MH Wang… - Medicinal research …, 2015 - Wiley Online Library
Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications

B Deng, W Kong, X Shen, C Han, Z Zhao… - Journal of Translational …, 2024 - Springer
Lipid metabolism is widely reprogrammed in tumor cells. Lipid droplet is a common
organelle existing in most mammal cells, and its complex and dynamic functions in …

Mammalian mitochondrial ribosomal small subunit (MRPS) genes: A putative role in human disease

G Gopisetty, R Thangarajan - Gene, 2016 - Elsevier
Mitochondria are prominently understood as power houses producing ATP the primary
energy currency of the cell. However, mitochondria are also known to play an important role …

Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2

M Mushtaq, L Kovalevska, S Darekar… - Proceedings of the …, 2020 - National Acad Sciences
Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem
cell maintains a balance between proliferation, quiescence, and regeneration via …

A novel role for DGATs in cancer

MJ Hernández-Corbacho, LM Obeid - Advances in biological regulation, 2019 - Elsevier
Dysregulation of lipid metabolism is pathologically associated to metabolic diseases such as
atherogenic dyslipidemia, hepatic steatosis, obesity and type 2 diabetes. Up-regulation of …

[HTML][HTML] Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

M Mints, M Mushtaq, N Iurchenko, L Kovalevska… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Endometrial cancer (EC) is one of the most frequent causes of cancer death among women
in developed countries. Histopathological diagnosis and imaging techniques for EC are …

Role of the RB-interacting proteins in stem cell biology

M Mushtaq, HV Gaza, EV Kashuba - Advances in cancer research, 2016 - Elsevier
Human retinoblastoma gene RB1 is the first tumor suppressor gene (TSG) isolated by
positional cloning in 1986. RB is extensively studied for its ability to regulate cell cycle by …

The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells

M Mushtaq, L Jensen, S Davidsson, OV Grygoruk… - Scientific Reports, 2018 - nature.com
We have earlier found abnormal expression of the mitochondrial ribosomal protein S18-2
(MRPS18-2, S18-2) in endometrial cancer, compared to the expression in hyperplasia and …

A large set of estrogen receptor β‐interacting proteins identified by tandem affinity purification in hormone‐responsive human breast cancer cell nuclei

G Nassa, R Tarallo, C Ambrosino, A Bamundo… - …, 2011 - Wiley Online Library
Estrogen receptors α (ER‐α) and β (ER‐β) play distinct biological roles in onset and
progression of hormone‐responsive breast cancer, with ER‐β exerting a modulatory activity …