The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

The previous edition of The Bethesda System for Reporting Thyroid Cytopathology provided
important updates and advances in the practice of thyroid cytopathology. It was inspired by …

Background: The American Thyroid Association (ATA), the European Association of Nuclear
Medicine, the European Thyroid Association, and the Society of Nuclear Medicine and …

Restoration of Iodine Uptake with Larotrectinib In a woman with thyroid cancer expressing
an EML4-NTRK3 fusion gene, the cancer had become refractory to radioactive iodine when …

The treatment of advanced, radioiodine refractory, differentiated thyroid cancers (RR-DTCs)
has undergone major advancements in the last decade, causing a paradigm shift in the …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues. NIS …

Cellular retinoic acid-binding protein 2 (CRABP2) participates in retinoid partitioning
between different nuclear receptors. Recently, we identified that CRABP2 is one of the …

Simple Summary According to the American Cancer Society, approximately 53,000 new
cases of thyroid cancer were diagnosed and more than 2200 people died from the disease …

Background: Patients who have metastatic differentiated thyroid cancer (mDTC) frequently
have negative diagnostic and/or post-therapy radioiodine scans. As a result, 131I therapy is …