A weight of evidence review on the mode of action, adversity, and the human relevance of xylene's observed thyroid effects in rats

K Morris-Schaffer, L Higgins, NA Kocabas… - Critical Reviews in …, 2025 - Taylor & Francis
Xylene substances have wide industrial and consumer uses and are currently undergoing
dossier and substance evaluation under Registration, Evaluation, Authorization and …

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny–part II: how can key events …

S Marty, M Beekhuijzen, A Charlton… - Critical Reviews in …, 2021 - Taylor & Francis
The current understanding of thyroid-related adverse outcome pathways (AOPs) with
adverse neurodevelopmental outcomes in mammals has been reviewed. This served to …

Technical evaluation and standardization of the human thyroid microtissue assay

B Foley, K Hopperstad, J Gamble, SG Lynn… - Toxicological …, 2024 - academic.oup.com
The success and sustainability of US EPA efforts to reduce, refine, and replace in vivo
animal testing depends on the ability to translate toxicokinetic and toxicodynamic data from …

Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil …

K Minami, H Suto, A Sato, K Ogata, T Kosaka… - Regulatory Toxicology …, 2023 - Elsevier
Concern has been raised that thyroid hormone disruptors (THDs) may potentially interfere
with the developing brain, but effects of mild suppression of maternal THs by environmental …

The subchronic toxicity of higher olefins in Han Wistar rats

Q Shi, MG Penman, JC Carrillo… - BMC Pharmacology and …, 2024 - Springer
Higher olefins (HO) are a category of unsaturated hydrocarbons widely used in industry
applications to make products essential for daily human life. Establishing safe exposure …

[HTML][HTML] Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase …

W Bomann, H Tinwell, P Jenkinson… - Regulatory Toxicology and …, 2021 - Elsevier
Metribuzin is a herbicide that inhibits photosynthesis and has been used for over 40 years.
Its main target organ is the liver and to some extent the kidney in rats, dogs, and rabbits …

Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat

KL O'Shaughnessy, AL Sasser, KS Bell… - Toxicological …, 2024 - academic.oup.com
Evaluating the neurodevelopmental effects of thyroid-disrupting chemicals is challenging.
Although some standardized developmental and reproductive toxicity studies recommend …

Enhanced molecular recognition with longer chain crosslinkers in molecularly imprinted polymers for an efficient separation of TR active substances

T Kubo, M Yagishita, T Tanigawa, S Konishi-Yamada… - RSC …, 2024 - pubs.rsc.org
Molecular imprinting technology has been widely studied as a technique to obtain molecular
recognition by artificial means. Selecting functional monomers or polymerization conditions …

Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China

Q Hou, H Zou, S Zhang, J Lin, W Nie, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Aims Neonatal metabolites are very important in neonatal disease screening, and maternal
thyroid hormones play an important role in fetal and neonatal health. Our study aimed to …

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny–Part IV: the ECETOC and …

S Melching-Kollmuss, K Bothe, A Charlton… - Critical Reviews in …, 2023 - Taylor & Francis
Abstract Following the European Commission Endocrine Disruptor Criteria, substances shall
be considered as having endocrine disrupting properties if they (a) elicit adverse effects,(b) …