Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …

Cholesterol and phosphatidyl inositol 4, 5-bisphosphate (PIP2) are hydrophobic molecules
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …

Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …

Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …

Talin regulates crucial cellular functions, including cell adhesion and motility, and affects
human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the …

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability
to intervene and restore them. Developing technologies that can precisely interface with any …

Abstract TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K 2P) channels
mediate background potassium currents and regulate cellular excitability in many different …

Abstract TWIK related K+ channel (TREK-1) is a mechano-and anesthetic sensitive channel
that when activated attenuates pain and causes anesthesia. Recently the enzyme …

TWIK-related potassium channel 1 (TREK1), a two-pore-domain mammalian potassium (K+)
channel, regulates the resting potential across cell membranes, presenting a promising …

The plasma membrane is a well-organized structure of lipids and proteins, segmented into
lipid compartments under 200 nm in size. This specific spatial patterning is crucial for the …