Biology of HER2 and its importance in breast cancer

Y Yarden - Oncology, 2001 - karger.com
Human epidermal growth factor receptor-2 (HER2/erbB-2) belongs to a family of four
transmembrane receptors involved in signal transduction pathways that regulate cell growth …

Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy

S Choi, JN Myers - Journal of dental research, 2008 - journals.sagepub.com
The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring
the accumulation of multiple genetic alterations, influenced by a patient's genetic …

Advances in the biology of oral cancer

PK Tsantoulis, NG Kastrinakis, AD Tourvas, G Laskaris… - Oral oncology, 2007 - Elsevier
The incidence of oral cancer remains high and is associated with many deaths in both
Western and Asian countries. Several risk factors for the development of oral cancer are now …

The HER-2/neu Oncogene in Tumors of the Gastrointestinal Tract

JS Ross, B McKenna - Cancer investigation, 2001 - Taylor & Francis
The HER-2/neu oncogene is localized to chromosome 17q and shares significant homology
with the epidermal growth factor receptor. As a result of its potential role in the selection of …

Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members

W Xia, YK Lau, HZ Zhang, FY Xiao, DA Johnston… - Clinical Cancer …, 1999 - AACR
In a series of 111 patients with squamous cell carcinoma (SCC), we used
immunohistochemistry to examine the expression levels of four epidermal growth factor …

Systems and methods for cell subpopulation analysis

P Gascoyne, JV Vykoukal, FF Becker - US Patent 6,790,330, 2004 - Google Patents
Systems, apparatuses and methods for cell isolation and analysis. Cells are introduced into
a dielectrophoretic pre filter including one or more trapping electrodes configured to trap at …

Interaction between the adhesion receptor, CD44, and the oncogene product, p185 HER2, promotes human ovarian tumor cell activation

LYW Bourguignon, H Zhu, A Chu, N Iida… - Journal of Biological …, 1997 - ASBMB
In this study we have examined the interaction between CD44s (the standard form) and the
p185 HER2 proto-oncogene in the ovarian carcinoma cell line. Surface biotinylation …

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

GR Thomas, H Nadiminti… - International journal of …, 2005 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract
and can destroy the structure and function of organs involved in voice, speech, taste, smell …

Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated …

BBY Ma, TCW Poon, KF To, B Zee… - Head & Neck …, 2003 - Wiley Online Library
Background. This study prospectively examines the prognostic role of p53 oncoprotein
(p53), Ki67‐antigen (Ki67), tumor angiogenesis (MVD), epidermal growth factor receptor …

Prognostic relevance of molecular markers of oral cancer—a review

H Schliephake - International journal of oral and maxillofacial surgery, 2003 - Elsevier
The aim of the present article was to review the current knowledge on the prognostic value
of tumour marker in the treatment of oral squamous cell carcinoma (OSCC). The literature of …