Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …

Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most
common cause of dementia in the elderly. The complexity of AD has hindered the …

An analysis of 156 published clinical candidates from the Journal of Medicinal Chemistry
between 2018 and 2021 was conducted to identify lead generation strategies most …

Thiazoles have attracted much synthetic interest due to their wide variety of biological
properties and are important members of heterocyclic compounds. In recent years, studies …

Alzheimer's disease (AD) is associated with marked atrophy of the cerebral cortex and
accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by …

Abstract β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors offer the
potential of disease-modifying treatment for Alzheimer's disease (AD). Since 2014, major …

Disease-modifying therapies (DMT) for Alzheimer's disease (AD) are highly longed-for. In
this quest, anti-amyloid therapies take center stage supported by genetic facts that highlight …

After identification of lead compound 6, 5-amino-1, 4-oxazine BACE1 inhibitors were
optimized in order to improve potency, brain penetration, and metabolic stability. Insertion of …

Alzheimer's disease (AD) involves complex pathological mechanisms. Secretases include
membrane protein extracellular structural domain proteases and intramembrane proteases …