Background: Comorbidity is an area of increasing interest in multiple sclerosis (MS).
Objective: The objective of this review is to estimate the incidence and prevalence of …

Zinc is an essential trace element for living organisms and their biological processes. Zinc
plays a key role in more than 300 enzymes and it is involved in cell communication …

Self tolerance loss is fundamental to autoimmunity. While understanding of immune
regulation is expanding rapidly, the mechanisms causing loss of tolerance in most …

Autoimmune diseases cumulatively affect 5–10% of the industrial world population and are
a significant cause of morbidity and mortality. In recent decades rates are rising worldwide …

Background: Findings regarding the prevalence of vascular comorbidities in multiple
sclerosis (MS) are conflicting. Objective: The objective of this review is to estimate the …

Background: As new therapies emerge which increase the risk of autoimmune disease it is
increasingly important to understand the incidence of autoimmune disease in multiple …

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the
pathophysiology of this disease shares many similarities with human type 1 diabetes. Since …

The utility of genotype imputation in genome-wide association studies is increasing as
progressively larger reference panels are improved and expanded through whole-genome …

Background IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R
system involved in the immune response and in the control of autoimmunity. Methods and …

Oligodendrocytes not only produce myelin to facilitate nerve impulse conduction, but are
also essential metabolic partners of the axon. Oligodendrocyte loss and myelin destruction …