Mouse models of atherosclerosis and their suitability for the study of myocardial infarction

P Golforoush, DM Yellon, SM Davidson - Basic research in cardiology, 2020 - Springer
Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and
tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in …

[HTML][HTML] Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases

M Barteková, A Adameová, A Görbe… - Free Radical Biology …, 2021 - Elsevier
Cardiometabolic diseases (CMDs) are metabolic diseases (eg, obesity, diabetes,
atherosclerosis, rare genetic metabolic diseases, etc.) associated with cardiac pathologies …

Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological …

P Ferdinandy, I Andreadou, GF Baxter, HE Bøtker… - Pharmacological …, 2023 - Elsevier
Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling

I Andreadou, A Daiber, GF Baxter, MF Brizzi… - Free Radical Biology …, 2021 - Elsevier
The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

Octacosanol and health benefits: Biological functions and mechanisms of action

Y Zhou, F Cao, F Luo, Q Lin - Food Bioscience, 2022 - Elsevier
Octacosanol is a widely distributed natural higher aliphatic alcohol that can be isolated and
purified from rice bran, sugarcane, beeswax, insect wax, etc. Octacosanol exerts various …

Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

[HTML][HTML] Harnessing the power of bioprinting for the development of next-generation models of thrombosis

Y Liu, T Huang, NA Yap, K Lim, LA Ju - Bioactive Materials, 2024 - Elsevier
Thrombosis, a leading cause of cardiovascular morbidity and mortality, involves the
formation of blood clots within blood vessels. Current animal models and in vitro systems …

PCSK9 in myocardial infarction and cardioprotection: importance of lipid metabolism and inflammation

I Andreadou, M Tsoumani, G Vilahur… - Frontiers in …, 2020 - frontiersin.org
Extensive evidence from epidemiologic, genetic, and clinical intervention studies has
indisputably shown that elevated low-density lipoprotein cholesterol (LDL-C) concentrations …

The influence of metabolic risk factors on the inflammatory response triggered by myocardial infarction: bridging pathophysiology to treatment

L Ramos-Regalado, S Alcover, L Badimon, G Vilahur - Cells, 2024 - mdpi.com
Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective
cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled …

Recombinant human soluble domain of CD39L3 and ticagrelor: cardioprotective effects in experimental myocardial infarction

G Vilahur, M Radike, P Sutelman… - European Heart …, 2024 - academic.oup.com
Abstract Background and Aims The ecto–nucleoside triphosphate diphosphohydrolases of
the CD39 family degrade ATP and ADP into AMP, which is converted into adenosine by the …