RNAi is applied as a new and safe method for pest control in agriculture but efficiency and
specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been …

Understanding schistosome biology is still a challenging mission. The reproductive biology
of this parasitic trematode is closely associated with the pathologic consequences of …

CRISPR/Cas9-based genome editing has yet to be reported in species of the
Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma …

Background. At least 250 million people worldwide suffer from schistosomiasis, caused by
Schistosoma worms. Genome sequences for several Schistosoma species are available …

The identification and characterization of genomic safe harbor sites (GSHs) can facilitate
consistent transgene activity with minimal disruption to the host cell genome. We combined …

The efficiency of the RNA-guided As Cas12a nuclease of Acidaminococcus sp. was
compared with Sp Cas9 from Streptococcus pyogenes, for functional genomics in …

Schistosomiasis is a neglected disease of poverty that is caused by several species of the
trematode flatworm, Schistosoma. Treatment relies on just one drug, the …

Schistosoma mansoni is the causative agent of intestinal schistosomiasis and infects~ 54
million people annually, causing significant mortality and morbidity. This parasitic trematode …

Linkage mapping–utilizing experimental genetic crosses to examine cosegregation of
phenotypic traits with genetic markers–is now 100 years old. Schistosome parasites are …

More than 300 million people are infected each year with parasitic flatworms such as hydatid
tapeworms and blood fluke schistosomes. The diseases caused by such parasitic helminths …