Targeting key proximal drivers of type 2 inflammation in disease
NA Gandhi, BL Bennett, NMH Graham… - Nature reviews Drug …, 2016 - nature.com
Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …
IL-4 and IL-13 signaling in allergic airway disease
N Gour, M Wills-Karp - Cytokine, 2015 - Elsevier
Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …
[HTML][HTML] Risankizumab in severe asthma—a phase 2a, placebo-controlled trial
Background Interleukin-23 has been implicated in airway inflammation that is mediated by
type 2 and type 17 cytokines. Whether targeting interleukin-23 in the treatment of asthma …
type 2 and type 17 cytokines. Whether targeting interleukin-23 in the treatment of asthma …
The intriguing role of interleukin 13 in the pathophysiology of asthma
G Marone, F Granata, V Pucino, A Pecoraro… - Frontiers in …, 2019 - frontiersin.org
Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma.
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in …
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in …
IL-13 effector functions
TA Wynn - Annual review of immunology, 2003 - annualreviews.org
IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class
II expression, promoted IgE class switching and inhibited inflammatory cytokine production …
II expression, promoted IgE class switching and inhibited inflammatory cytokine production …
Airway smooth muscle pathophysiology in asthma
B Camoretti-Mercado, RF Lockey - Journal of Allergy and Clinical …, 2021 - Elsevier
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …
constitutes an important target for treatment. These cells control muscle tone and thus …
Engineering the IL‐4/IL‐13 axis for targeted immune modulation
ZJ Bernstein, A Shenoy, A Chen… - Immunological …, 2023 - Wiley Online Library
The structurally and functionally related interleukin‐4 (IL‐4) and IL‐13 cytokines play pivotal
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …
Interleukin‐13 in asthma pathogenesis
M Wills‐Karp - Immunological reviews, 2004 - Wiley Online Library
Bronchial asthma is a complex disorder that is thought to arise as a result of aberrant T‐
lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms …
lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms …
The role of T lymphocytes in the pathogenesis of asthma
M Larché, DS Robinson, AB Kay - Journal of Allergy and Clinical …, 2003 - Elsevier
Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …
Proinflammatory pathways in the pathogenesis of asthma
RS Peebles, MA Aronica - Clinics in chest medicine, 2019 - chestmed.theclinics.com
The most recent Guidelines for the Diagnosis and Management of Asthma from the National
Asthma Education and Prevention Program define the disease as follows:“Asthma is a …
Asthma Education and Prevention Program define the disease as follows:“Asthma is a …