Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Summary 2022 corresponds to the 100th anniversary of the discovery of glucagon. This
TimeCapsule aims to recall the main steps leading to the discovery, characterisation, and …

Aim To report two phase I studies of the novel subcutaneous glucagon‐like peptide‐1
receptor/glucagon receptor (GLP‐1R/GCGR) dual agonist BI 456906 versus placebo in …

Background Obesity is a widespread and chronic condition that requires long-term
management; research into additional targets to improve treatment outcomes remains a …

In this study, we aimed to explore the antidiabetic effects of Lactobacillus rhamnosus LRa05
on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data …

Obesity is a chronic, multifactorial, relapsing disease. Despite multicomponent lifestyle
interventions, including pharmacotherapy, maintaining bodyweight loss is challenging for …

Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is
regulated by posttranslational modifications of key lipolytic enzymes. However, less is …

Context Reduced estrogen levels in postmenopausal women predispose them to metabolic
side effects, including insulin resistance and type 2 diabetes; however, the cellular …

Pathophysiological pathways that are induced by chronic hyperglycemia negatively impact
lipid metabolism. Thus, diabetes is commonly accompanied by varying degrees of …

For at least 50 years, the prevailing view has been that the adenylate cyclase (AC)/cyclic
AMP (cAMP)/protein kinase A pathway is the predominant signal mediating the hepatic …