Global epistasis in plasmid-mediated antimicrobial resistance

J DelaFuente, J Diaz-Colunga, A Sanchez… - Molecular systems …, 2024 - embopress.org
Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative
plasmids play a key role in the dissemination of AMR genes among bacterial pathogens …

The fitness cost of horizontally transferred and mutational antimicrobial resistance in Escherichia coli

M Vanacker, N Lenuzza, JP Rasigade - Frontiers in Microbiology, 2023 - frontiersin.org
Antimicrobial resistance (AMR) in bacteria implies a tradeoff between the benefit of
resistance under antimicrobial selection pressure and the incurred fitness cost in the …

The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria

A Fernández-Calvet, L Toribio-Celestino… - …, 2023 - microbiologyresearch.org
Antimicrobial resistance (AMR) in bacteria is a major public health problem. The main route
for AMR acquisition in clinically important bacteria is the horizontal transfer of plasmids …

Commensal Fitness Advantage May Contribute to the Global Dissemination of Multidrug-Resistant Lineages of Bacteria—The Case of Uropathogenic E. coli

M Fuzi, E Sokurenko - Pathogens, 2023 - mdpi.com
It is widely accepted that favorable fitness in commensal colonization is one of the prime
facilitators of clonal dissemination in bacteria. The question arises as to what kind of fitness …

Genomic Epidemiology of C2/H30Rx and C1-M27 Subclades of Escherichia coli ST131 Isolates from Clinical Blood Samples in Hungary

K Tóth, I Damjanova, L Laczkó, L Buzgó, V Lesinszki… - Antibiotics, 2024 - mdpi.com
Extended-spectrum β-lactamase-producing Escherichia coli ST131 has become widespread
worldwide. This study aims to characterize the virulome, resistome, and population structure …