Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Until recently, class A penicillin‐binding proteins (aPBPs) were the only enzymes known to
catalyze glycan chain polymerization from lipid II in bacteria. Hence, the discovery of two …

Intrinsically disordered protein regions (IDRs) have been implicated in diverse nuclear and
cytoplasmic functions in eukaryotes, but their roles in bacteria are less clear. Here, we report …

Staphylococcus aureus is a Gram-positive pathogen responsible for antibiotic-resistant
infections. To identify vulnerabilities in cell envelope biogenesis that may overcome …

GpsB links peptidoglycan synthases to other proteins that determine the shape of the
respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn) and other low‐GC …

Reproduction in the bacterial kingdom predominantly occurs through binary fission—a
process in which one parental cell is divided into two similarly sized daughter cells. How cell …

Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by
a protein complex consisting of at least 14 different protein elements; known as the …

Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many
antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and …

Synthesis of capsular polysaccharide (CPS), an important virulence factor of pathogenic
bacteria, is modulated by the CpsBCD phosphoregulatory system in Streptococcus …

Bacterial peptidoglycan (PG) synthesis requires strict spatiotemporal organization to
reproduce specific cell shapes. In ovoid‐shaped Streptococcus pneumoniae (Spn), septal …