In kidney transplantation, ongoing alloimmune processes—commonly triggered by HLA
incompatibilities—can trigger chronic transplant rejection, affecting the microcirculation and …

Chronic graft rejection represents a significant threat to long-term graft survival. Early
diagnosis, understanding of the immunological mechanisms and appropriate therapeutic …

Background. Initial analysis of liver transplant biopsies in the INTERLIVER study
(ClinicalTrials. gov; unique identifier NCT03193151) using rejection-associated transcripts …

Many patients with transplanted kidneys ultimately lose them because of antibody-mediated
rejection, yet approved therapies are lacking. Multiple mechanisms appear to be involved …

Antibody-mediated rejection (AMR) is a major cause of graft failure limiting long-term graft
survival after kidney transplantation. Current diagnostic strategy to detect AMR is suboptimal …

Transcript analyses highlight an important contribution of natural killer (NK) cells to
microvascular inflammation (MVI) in antibody-mediated rejection (ABMR), but only few …

Pathogenic long-lived plasma cells (LLPCs) secrete autoreactive antibodies, exacerbating
autoimmune diseases and complicating solid organ transplantation. Targeted elimination of …

Background Renal transplant recipients with donor-specific anti-HLA antibodies are at an
increased risk of antibody-mediated rejection (ABMR). Early protocolized renal biopsies may …

Targeting of CD38 has been posited as a potential therapeutic avenue for the treatment of
immune-mediated conditions. A phase 2 study now reports promising safety, tolerability and …

The role of the complement system in antibody mediated rejection (AMR) emerged in the
last decades, and the demonstration of the presence of complement fragments in renal …