Cytomegalovirus (CMV) infection remains a major complication of solid organ transplantation. Because of management of CMV is variable among transplant centers, in …
B Tönshoff - Pediatric Pharmacotherapy, 2020 - Springer
The goal of immunosuppressive therapy post-transplantation in pediatric renal transplant recipients is to prevent acute and chronic rejection while minimizing drug side effects. Most …
S Bak, S Tischer, A Dragon, S Ravens, L Pape… - Frontiers in …, 2018 - frontiersin.org
Cytomegalovirus (CMV) infection/reactivation remains among the most important complications of immunosuppression after transplantation. However, recent clinical …
D Puliyanda, Z Barday, Z Barday, A Freedman… - Seminars in …, 2023 - Elsevier
Kidney transplantation is the treatment of choice for all patients with end-stage kidney disease, including pediatric patients. Graft survival in pediatrics was lagging behind adults …
Background Pharmacokinetic monitoring is insufficient to estimate the intensity of immunosuppression after transplantation. Virus-specific T cells correlate with both virus …
L Tan, N Sato, A Shiraki, M Yanagita, Y Yoshida… - Antiviral research, 2019 - Elsevier
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex …
A Prytuła, T van Gelder - Pediatric Nephrology, 2019 - Springer
The calcineurin inhibitor tacrolimus, cornerstone of most immunosuppressive regimens, is a drug with a narrow therapeutic window: underexposure can lead to allograft rejection and …
FA Scaggs Huang, L Danziger-Isakov - Pediatric Nephrology, 2019 - Springer
Renal transplantation is a vital treatment option in children with ESRD with more than 10,000 pediatric kidney transplants and survival rates of greater than 80% at 10 years post …
SS Balani, S Sadiq, CJ Jensen, SJ Kizilbash - Frontiers in Pediatrics, 2023 - frontiersin.org
Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality …