The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation

CN Kotton, D Kumar, AM Caliendo, S Huprikar… - …, 2018 - journals.lww.com
Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common
complications affecting solid organ transplant recipients, conveying higher risks of …

Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

J Torre-Cisneros, JM Aguado, JJ Caston… - Transplantation …, 2016 - Elsevier
Cytomegalovirus (CMV) infection remains a major complication of solid organ
transplantation. Because of management of CMV is variable among transplant centers, in …

Immunosuppressants in organ transplantation

B Tönshoff - Pediatric Pharmacotherapy, 2020 - Springer
The goal of immunosuppressive therapy post-transplantation in pediatric renal transplant
recipients is to prevent acute and chronic rejection while minimizing drug side effects. Most …

Selective effects of mTOR inhibitor sirolimus on naïve and CMV-specific T cells extending its applicable range beyond immunosuppression

S Bak, S Tischer, A Dragon, S Ravens, L Pape… - Frontiers in …, 2018 - frontiersin.org
Cytomegalovirus (CMV) infection/reactivation remains among the most important
complications of immunosuppression after transplantation. However, recent clinical …

Children are not small adults: similarities and differences in renal transplantation between adults and pediatrics

D Puliyanda, Z Barday, Z Barday, A Freedman… - Seminars in …, 2023 - Elsevier
Kidney transplantation is the treatment of choice for all patients with end-stage kidney
disease, including pediatric patients. Graft survival in pediatrics was lagging behind adults …

Steering transplant immunosuppression by measuring virus-specific T cell levels: the randomized, controlled IVIST trial

T Ahlenstiel-Grunow, X Liu, R Schild, J Oh… - Journal of the …, 2021 - journals.lww.com
Background Pharmacokinetic monitoring is insufficient to estimate the intensity of
immunosuppression after transplantation. Virus-specific T cells correlate with both virus …

Everolimus delayed and suppressed cytomegalovirus DNA synthesis, spread of the infection, and alleviated cytomegalovirus infection

L Tan, N Sato, A Shiraki, M Yanagita, Y Yoshida… - Antiviral research, 2019 - Elsevier
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of
cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex …

Clinical aspects of tacrolimus use in paediatric renal transplant recipients

A Prytuła, T van Gelder - Pediatric Nephrology, 2019 - Springer
The calcineurin inhibitor tacrolimus, cornerstone of most immunosuppressive regimens, is a
drug with a narrow therapeutic window: underexposure can lead to allograft rejection and …

Infectious disease risks in pediatric renal transplantation

FA Scaggs Huang, L Danziger-Isakov - Pediatric Nephrology, 2019 - Springer
Renal transplantation is a vital treatment option in children with ESRD with more than
10,000 pediatric kidney transplants and survival rates of greater than 80% at 10 years post …

Prevention and management of CMV infection in pediatric solid organ transplant recipients

SS Balani, S Sadiq, CJ Jensen, SJ Kizilbash - Frontiers in Pediatrics, 2023 - frontiersin.org
Human cytomegalovirus (CMV) remains one of the most common opportunistic infections
following solid organ transplantation in children. CMV causes morbidity and mortality …