HIV prevention transformed: the new prevention research agenda
We have entered a new era in HIV prevention whereby priorities have expanded from
biomedical discovery to include implementation, effectiveness, and the effect of combination …
biomedical discovery to include implementation, effectiveness, and the effect of combination …
[PDF][PDF] Guidance on pre-exposure oral prophylaxis (PrEP) for serodiscordant couples, men who have sex with men and transgender women at high risk of HIV in …
World Health Organization - 2012 - apps.who.int
Background More than 34 million people globally are living with HIV. A number of
prevention methods are available, from condoms to male circumcision, PMTCT or clean …
prevention methods are available, from condoms to male circumcision, PMTCT or clean …
[HTML][HTML] Tenofovir-based preexposure prophylaxis for HIV infection among African women
Background Reproductive-age women need effective interventions to prevent the
acquisition of human immunodeficiency virus type 1 (HIV-1) infection. Methods We …
acquisition of human immunodeficiency virus type 1 (HIV-1) infection. Methods We …
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women.
We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in …
We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in …
[HTML][HTML] Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
Background Antiretroviral preexposure prophylaxis is a promising approach for preventing
human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations …
human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations …
Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men
PL Anderson, DV Glidden, A Liu… - Science translational …, 2012 - science.org
Drug concentrations associated with protection from HIV-1 acquisition have not been
determined. We evaluated drug concentrations among men who have sex with men in a …
determined. We evaluated drug concentrations among men who have sex with men in a …
[HTML][HTML] Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
RM Grant, JR Lama, PL Anderson… - … England Journal of …, 2010 - Mass Medical Soc
Background Antiretroviral chemoprophylaxis before exposure is a promising approach for
the prevention of human immunodeficiency virus (HIV) acquisition. Methods We randomly …
the prevention of human immunodeficiency virus (HIV) acquisition. Methods We randomly …
[HTML][HTML] HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention
Background: Antiretroviral pre-exposure prophylaxis (PrEP) is a novel HIV prevention
strategy for which adherence is a known determinant of efficacy. Blood concentrations of …
strategy for which adherence is a known determinant of efficacy. Blood concentrations of …
Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study
JM Baeten, T Palanee-Phillips, NM Mgodi, AJ Mayo… - The lancet HIV, 2021 - thelancet.com
Background Two phase 3 clinical trials showed that use of a monthly vaginal ring containing
25 mg dapivirine was well tolerated and reduced HIV-1 incidence in women by …
25 mg dapivirine was well tolerated and reduced HIV-1 incidence in women by …
Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission
KB Patterson, HA Prince, E Kraft, AJ Jenkins… - Science translational …, 2011 - science.org
A mainstay of strategies to prevent HIV-1 transmission is to use antiretroviral therapy (ART)
for pre-exposure prophylaxis (PrEP). Critical to the design and interpretation of PrEP …
for pre-exposure prophylaxis (PrEP). Critical to the design and interpretation of PrEP …