Type 2 diabetes: a sacrifice program handling energy surplus
J Ye, J Yin - Life Metabolism, 2024 - academic.oup.com
Type 2 diabetes mellitus (T2DM) is closely associated with obesity, while interactions
between the two diseases remain to be fully elucidated. To this point, we offer this …
between the two diseases remain to be fully elucidated. To this point, we offer this …
Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment
N Stefan, H Yki-Järvinen… - The Lancet Diabetes & …, 2024 - thelancet.com
The global epidemic of metabolic dysfunction-associated steatotic liver disease (MASLD) is
increasing worldwide. People with MASLD can progress to cirrhosis and hepatocellular …
increasing worldwide. People with MASLD can progress to cirrhosis and hepatocellular …
Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data
S Ramne, M García-Ureña, MP Gillum, L Ängquist… - Molecular …, 2024 - Elsevier
Objectives Experimental and genetic studies suggest that fibroblast growth factor 21
(FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation …
(FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation …
Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian …
Abstract Background Previous studies, including Mendelian randomization (MR), have
demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of …
demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of …
Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases
J Li, X Ma, C Yin - Scientific Reports, 2024 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is the predominant cause of liver pathology.
Current evidence highlights plasma proteins as potential therapeutic targets. However, their …
Current evidence highlights plasma proteins as potential therapeutic targets. However, their …
Sex-specific impact of GCKR rs1260326 polymorphism on metabolic traits in an older Japanese population: the Bunkyo Health Study
S Sakamoto, S Kakehi, A Abudurezake… - Therapeutic …, 2024 - journals.sagepub.com
Background: Metabolic syndrome involves health problems influenced by aging and
genetics. The glucokinase regulatory protein (GCKR) rs1260326 polymorphism (Leu446) is …
genetics. The glucokinase regulatory protein (GCKR) rs1260326 polymorphism (Leu446) is …
[HTML][HTML] Reductive stress—a common metabolic feature of obesity and cancer
M Luo, X Ma, J Ye - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Reductive stress, characterized by rising level of NADH (nicotinamide adenine dinucleotide)
for a status of NADH/NAD+ ratio elevation, has been reported in obesity and cancer …
for a status of NADH/NAD+ ratio elevation, has been reported in obesity and cancer …
Diet pattern determines circulating FGF21 levels while distinct FGF21 variants influence diet pattern and FGF21 levels
S Ramne, M García-Ureña, MP Gillum, L Ängquist… - medRxiv, 2024 - medrxiv.org
Experimental and genetic studies suggest that FGF21 modulates macronutrient and alcohol
preferences. However, FGF21's regulation of human appetite remains elusive. To address …
preferences. However, FGF21's regulation of human appetite remains elusive. To address …
[HTML][HTML] Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism
J An, I Astapova, G Zhang, AL Cangelosi, O Ilkayeva… - …, 2024 - pmc.ncbi.nlm.nih.gov
Carbohydrate Response Element-Binding Protein (ChREBP) is a transcription factor that
activates key genes involved in glucose, fructose, and lipid metabolism in response to …
activates key genes involved in glucose, fructose, and lipid metabolism in response to …