A perspective on the potential risks of emerging contaminants to human and environmental health

LC Pereira, AO de Souza, MFF Bernardes… - … Science and Pollution …, 2015 - Springer
Technological, agricultural, and medical advances have improved the lifestyle of
humankind. However, these advances have caused new problems that affect the …

A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity

LG Costa, R de Laat, S Tagliaferri, C Pellacani - Toxicology letters, 2014 - Elsevier
Polybrominated diphenyl ethers (PBDEs), extensively used in the past few decades as flame
retardants in a variety of consumer products, have become world-wide persistent …

Neurotoxicity of brominated flame retardants:(in) direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system

MML Dingemans, M van den Berg… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background/objective: Polybrominated diphenyl ethers (PBDEs) and their hydroxylated (OH-
) or methoxylated forms have been detected in humans. Because this raises concern about …

Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis

L Dong, Q Sun, H Qiu, K Yang, B Xiao… - Journal of Pineal …, 2023 - Wiley Online Library
Abstract The neurotoxicity of 2, 2', 4, 4'‐tetrabromodiphenyl ether (PBDE‐47) is closely
linked to mitochondrial abnormalities while mitophagy is vital for mitochondrial homeostasis …

Impact of endocrine-disrupting chemicals on neural development and the onset of neurological disorders

M Kajta, AK Wójtowicz - Pharmacological Reports, 2013 - Springer
Even though high doses of organic pollutants are toxic, relatively low concentrations have
been reported to cause long-term alterations in functioning of individual organisms …

Cellular and physiological mechanisms of halogenated and organophosphorus flame retardant toxicity

L Khani, L Martin, Ł Pułaski - Science of the Total Environment, 2023 - Elsevier
Flame retardants (FRs) are chemical substances used to inhibit the spread of fire in
numerous industrial applications, and their abundance in modern manufactured products in …

Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells

AM Montalbano, GD Albano, G Anzalone, M Moscato… - Chemosphere, 2020 - Elsevier
Polybrominated diphenyl ethers (PBDEs) are widespread as flame-retardants in different
types of consumer products. PBDEs present in the air or dust and their inhalation can …

Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?

LG Costa, G Giordano - Neurotoxicology, 2011 - Elsevier
Polybrominated diphenyl ether (PBDE) flame retardants have become ubiquitous
environmental pollutants. The relatively higher body burden in toddlers and children has …

Developmental neurotoxicity: some old and new issues

G Giordano, LG Costa - International Scholarly Research …, 2012 - Wiley Online Library
The developing central nervous system is often more vulnerable to injury than the adult one.
Of the almost 200 chemicals known to be neurotoxic, many are developmental …

Neurotoxicity and risk assessment of brominated and alternative flame retardants

HS Hendriks, RHS Westerink - Neurotoxicology and teratology, 2015 - Elsevier
Brominated flame retardants (BFRs) are widely used chemicals that prevent or slow the
onset and spreading of fire. Unfortunately, many of these compounds pose serious threats …