M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
INTRODUCTION The characterization of the full spectrum of genetic variation is critical to understanding human health and disease. Recent technological advances have made it …
Most signals in genome-wide association studies (GWAS) of complex traits implicate noncoding genetic variants with putative gene regulatory effects. However, currently …
Both common and rare genetic variants influence complex traits and common diseases. Genome-wide association studies have identified thousands of common-variant …
Annotating the molecular basis of human disease remains an unsolved challenge, as 93% of disease loci are non-coding and gene-regulatory annotations are highly incomplete …
Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to …
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and diseases by aggregating information across multiple genetic variants identified from genome …
DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA,,,–and contain genetic variations associated with diseases and phenotypic traits,–. We created high …
Decades of research show that genes play an vital role in the etiology of attention deficit hyperactivity disorder (ADHD) and its comorbidity with other disorders. Family, twin, and …