The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …

Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …