Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Salivarian trypanosomes are the causative agents of several diseases of major social and
economic impact. The most infamous parasites of this group are the African subspecies of …

Eukaryotic organelle genomes are generally of conserved size and gene content within
phylogenetic groups. However, significant variation in genome structure may occur. Here …

Kinetoplast DNA (kDNA), the mitochondrial DNA of flagellated protozoa of the order
Kinetoplastida, is unique in its structure, function and mode of replication. It consists of few …

Two different RNA editing systems have been described in the kinetoplast-mitochondrion of
trypanosomatid protists. The first involves the precise insertion and deletion of U residues …

Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by
uridylate insertion and deletion. The often dramatic remodeling of pre-mRNA sequences is …

Mitochondrial genomes have been sequenced from a wide variety of organisms, including
an increasing number of parasites. They maintain some characteristics in common across …

In this review, we summarize the current knowledge concerning the eukaryotic protozoan
parasite Leishmania tarentolae, with a main focus on its potential for biotechnological …

Recent advances in in vitro systems and identification of putative enzymatic activities have
led to the acceptance of a modified 'enzyme cascade'model for U insertion/deletion RNA …

Kinetoplastids are protists defined by one of the most complex mitochondrial genomes in
nature, the kinetoplast. In the sleeping sickness parasite Trypanosoma brucei, the …