Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives

JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Flow-mediated endothelial mechanotransduction

PF Davies - Physiological reviews, 1995 - journals.physiology.org
Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

DN Ku, DP Giddens, CK Zarins… - Arteriosclerosis: An Official …, 1985 - Am Heart Assoc
Fluid velocities were measured by laser Doppler velocimetry under conditions of pulsatile
flow in a scale model of the human carotid bifurcation. Flow velocity and wall shear stress at …

Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions

JJ Wentzel, YS Chatzizisis, FJH Gijsen… - Cardiovascular …, 2012 - academic.oup.com
The heterogeneity of plaque formation, the vascular remodelling response to plaque
formation, and the consequent phenotype of plaque instability attest to the extraordinarily …

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

S Glagov, C Zarins, DP Giddens… - Archives of pathology & …, 1988 - europepmc.org
Atherosclerosis affects the major elastic and muscular arteries, but some vessels are largely
spared while others may be markedly diseased. The carotid bifurcation, the coronary …

Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

PF Davies, A Remuzzi, EJ Gordon… - Proceedings of the …, 1986 - National Acad Sciences
The effects of hemodynamic forces upon vascular endothelial cell turnover were studied by
exposing contact-inhibited confluent cell monolayers to shear stresses of varying amplitude …

Pulsatile flow in the human left coronary artery bifurcation: average conditions

X He, DN Ku - 1996 - asmedigitalcollection.asme.org
The localization of atherosclerosis in the coronary arteries may be governed by local
hemodynamic features. In this study, the pulsatile hemodynamics of the left coronary artery …

Role of hemodynamic shear stress in cardiovascular disease

E Cecchi, C Giglioli, S Valente, C Lazzeri, GF Gensini… - Atherosclerosis, 2011 - Elsevier
Atherosclerosis is the main cause of morbidity and mortality in the Western world.
Inflammation and blood flow alterations are new markers emerging as possible …

The influence of the non-Newtonian properties of blood on the flow in large arteries: steady flow in a carotid bifurcation model

FJH Gijsen, FN van de Vosse, JD Janssen - Journal of biomechanics, 1999 - Elsevier
Laser Doppler anemometry experiments and finite element simulations of steady flow in a
three dimensional model of the carotid bifurcation were performed to investigate the …

Patient-specific modeling of cardiovascular mechanics

CA Taylor, CA Figueroa - Annual review of biomedical …, 2009 - annualreviews.org
Advances in numerical methods and three-dimensional imaging techniques have enabled
the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic …