One of the main problems of Chagas disease (CD), the parasitic infection caused by
Trypanosoma cruzi, is the lack of a completely satisfactory treatment, which is currently …

Calophyllum brasiliense and Mammea americana (Clusiaceae) are two trees from the
tropical rain forests of the American continent. A previous screening showed high …

Chagas disease is a tropical neglected disease endemic in Latin America caused by the
protozoan Trypanosoma cruzi. The parasite has four major life stages: epimastigote …

Trypanosoma cruzi is the protozoan parasite that causes Chagas disease or American
trypanosomiasis. Kinetoplastid parasites could be considered as model organisms for …

Over the last years an expanding family of small non-coding RNAs (sRNA) has been
identified in eukaryotic genomes which behave as sequence-specific triggers for mRNA …

Trypanosoma cruzi infects and replicates within a wide variety of immune and non-immune
cells. Here, we investigated early cellular responses induced in NIH-3T3 fibroblasts upon …

Neglected tropical diseases are a diverse group of communicable pathologies that mainly
prevail in tropical and subtropical regions. Thus, the objective of this work was to evaluate …

Trypanosoma cruzi has a complex life cycle involving four life stages: the replicative
epimastigotes and metacyclic trypomastigotes in the invertebrate host digestive tract, and …

Trypanosoma cruzi undergoes a biphasic life cycle that consists of four alternate
developmental stages. In vitro conditions to obtain a synchronic transformation and efficient …

This study offers an insight into why Trypanosoma cruzi epimastigotes lose their capacity to
differentiate into metacyclic forms, if maintained in culture media long-term through serial …