Heme has a critical role in the chemical framework of the cell as an essential protein cofactor
and signaling molecule that controls diverse processes and molecular interactions. Using a …

Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in
a large number of proteins. However, how heme is mobilized from the site of synthesis to the …

Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or
insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy …

Residue coevolution estimations coupled to machine learning methods are revolutionizing
the ability of protein structure prediction approaches to model proteins that lack clear …

Mono-and multiheme cytochromes c are post-translationally matured by the covalent
attachment of heme. For this, Escherichia coli employs the most complex type of maturation …

Although the individual structures and respiratory functions of cytochromes are well studied,
the structural basis for their assembly, including transport of heme for attachment, are …

Bacteriochlorophyll and chlorophyll serve as the most abundant and essential tetrapyrroles
in photoautotrophs, while heme is indispensable for all organisms. However, some parasites …

Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis.
The cytochrome c maturation system I, consisting of eight membrane proteins …

Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a
CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in …

Heme trafficking is a fundamental biological process, yet its direct study has been hampered
due to heme's tight intracellular regulation, heme cytotoxicity, and the transient nature of …