Placental function in maternal obesity
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
Environment and gene association with obesity and their impact on neurodegenerative and neurodevelopmental diseases
MT Flores-Dorantes, YE Díaz-López… - Frontiers in …, 2020 - frontiersin.org
Obesity is a multifactorial disease in which environmental conditions and several genes play
an important role in the development of this disease. Obesity is associated with …
an important role in the development of this disease. Obesity is associated with …
Obesity-induced inflammation exacerbates clonal hematopoiesis
SK Pasupuleti, B Ramdas, SS Burns… - The Journal of …, 2023 - Am Soc Clin Investig
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
Overweight and obesity in pregnancy: their impact on epigenetics
C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta
P Nogues, E Dos Santos, H Jammes, P Berveiller… - Clinical …, 2019 - Springer
Background It is well established that obesity is associated with dysregulation of the ratio
between the two major adipokines leptin and adiponectin. Furthermore, it was recently …
between the two major adipokines leptin and adiponectin. Furthermore, it was recently …
Neurodevelopmental programming of adiposity: contributions to obesity risk
AA Skowronski, RL Leibel, CA LeDuc - Endocrine Reviews, 2024 - academic.oup.com
This review analyzes the published evidence regarding maternal factors that influence the
developmental programming of long-term adiposity in humans and animals via the central …
developmental programming of long-term adiposity in humans and animals via the central …
Epigenetics and pregnancy: conditional snapshot or rolling event
Epigenetics modification such as DNA methylation can affect maternal health during the
gestation period. Furthermore, pregnancy can drive a range of physiological and molecular …
gestation period. Furthermore, pregnancy can drive a range of physiological and molecular …
Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring
Obesity, together with insulin resistance, promotes multiple metabolic abnormalities and is
strongly associated with an increased risk of chronic disease including type 2 diabetes …
strongly associated with an increased risk of chronic disease including type 2 diabetes …
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome
The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain
Background Maternal obesity prior to or during pregnancy influences fetal growth,
predisposing the offspring to increased risk for obesity across the life course. Placental …
predisposing the offspring to increased risk for obesity across the life course. Placental …