Current status on development of steroids as anticancer agents

A Gupta, BS Kumar, AS Negi - The Journal of steroid biochemistry and …, 2013 - Elsevier
Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …

Anticancer activity of diosgenin and its molecular mechanism

Q Ren, Q Wang, X Zhang, M Wang, H Hu… - Chinese journal of …, 2023 - Springer
Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea,
and Rhizoma polgonati, has shown high potential and interest in the treatment of various …

Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

JMV Hernández-Vázquez, H López-Muñoz… - European Journal of …, 2020 - Elsevier
Abstract (25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative
activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent …

Design, synthesis, and antifungal activities of hymexazol glycosides based on a biomimetic strategy

K Gao, Y Qin, L Wang, X Li, S Liu, R Xing… - Journal of Agricultural …, 2022 - ACS Publications
Hymexazol (HYM) is irreplaceable for treating soil-borne diseases due to its high efficiency
and low cost, as a broad-spectrum fungicide. However, when HYM is absorbed by plants, it …

[HTML][HTML] Hecogenin and its derivates: A pharmacology review

MA da Hora Borges, FRS Passos, JSS Quintans… - Biomedicine & …, 2023 - Elsevier
Despite the several uses of drugs from natural compounds in the pharmaceutical industry,
new molecules have been discovered and associated with pharmacological activities over …

Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin

AA Hamid, M Hasanain, A Singh, B Bhukya… - Steroids, 2014 - Elsevier
Diosgenin has been modified to furostane derivatives after opening the F-spiroacetal ring.
The aldehyde group at C26 in derivative 8 was unexpectedly transformed to the ketone 9 …

BCL3 exerts an oncogenic function by regulating STAT3 in human cervical cancer

H Zhao, W Wang, Q Zhao, G Hu, K Deng… - OncoTargets and …, 2016 - Taylor & Francis
Aberrant expression of oncogenes and/or tumor suppressors play a fundamental effect on
the pathogenesis and tumorigenicity of cervical cancer (CC). B-cell CLL/lymphoma 3 (BCL3) …

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

N Pathak, AS Negi - European Journal of Medicinal Chemistry, 2024 - Elsevier
Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin
obtained from various steroidal saponins and specially from dioscin. It possesses diverse …

[HTML][HTML] A review of the preparation, derivatization and functions of glucosamine and N-acetyl-glucosamine from chitin

K Gao, Y Qin, S Liu, L Wang, R Xing, HH Yu… - Carbohydrate Polymer …, 2023 - Elsevier
Chitin is a valuable and renewable carbohydrate. It is the second abundant but
underexploited carbohydrate polymer. Its monomers, glucosamine (GlcN) and N-acetyl …

Synthesis, Modification and Biological Activity of Diosgenyl β-d-Glycosaminosides: An Overview

D Grzywacz, B Liberek, H Myszka - Molecules, 2020 - mdpi.com
Saponins are a structurally diverse class of natural glycosides that possess a broad
spectrum of biological activities. They are composed of hydrophilic carbohydrate moiety and …