Hazards of current concentration-setting practices in environmental toxicology studies

JC Wolf, HE Segner - Critical Reviews in Toxicology, 2023 - Taylor & Francis
The setting of concentrations for testing substances in ecotoxicological studies is often
based on fractions of the concentrations that cause 50% mortality (LC50 or LD50) rather …

Environmental RNA as a Noninvasive tool for assessing toxic effects in fish: a proof-of-concept study using Japanese medaka exposed to pyrene

K Hiki, T Yamagishi, H Yamamoto - Environmental Science & …, 2023 - ACS Publications
Although environmental RNA (eRNA) is emerging as a noninvasive tool to assess the health
status of aquatic macroorganisms, the potential of eRNA in assessing chemical hazards …

The onset of active gill respiration in post-embryonic zebrafish (Danio rerio) larvae triggers an increased sensitivity to neurotoxic compounds

N Kämmer, L Erdinger, T Braunbeck - Aquatic Toxicology, 2022 - Elsevier
Originally designed as a general alternative to acute fish toxicity testing (AFT), the fish
embryo toxicity test (FET) has become subject to concerns with respect to neurotoxic …

Triphenylmethane dye (C52H54N4O12) is potentially a hazardous substance in edible freshwater fish at trace level: toxicity, hematology, biochemistry, antioxidants …

RK Poopal, R Ashwini, M Ramesh, B Li… - Environmental Science and …, 2023 - Springer
Abstract Malachite green (C52H54N4O12) is a synthetic dye that is used in textile industries
as a colorant and in aquaculture sectors to contain microbial damage. Aquatic …

Refining procedures within regulatory toxicology studies: improving animal welfare and data

H Prior, H Blunt, L Crossman, A McGuire, R Stow… - Animals, 2021 - mdpi.com
Simple Summary Before any new medicine can be administered to humans, or new
chemical marketed, some tests using animals such as fish, mice, rats, rabbits, dogs, or …

[HTML][HTML] Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data

G Pulido-Reyes, G Moreno-Martín… - Environmental …, 2024 - Elsevier
Fish acute toxicity tests are commonly used in aquatic environmental risk assessments,
being required in different international substances regulations. A general trend in the …

Is environmental risk assessment possible with the alternatives to acute fish toxicity test? Case study with pharmaceuticals

M Mlnaříková, M Pípal, L Bláhová, L Bláha - Environmental Sciences …, 2024 - Springer
Background Acute fish toxicity test (AFT) is one of the cornerstones of environmental risk
assessment (ERA) of chemicals for the aquatic environment. Despite many efforts to find an …

[HTML][HTML] Molecular variations to the proteome of zebrafish larvae induced by environmentally relevant copper concentrations

SL Green, E Silvester, S Dworkin, M Shakya, A Klein… - Aquatic Toxicology, 2024 - Elsevier
Contaminants are increasingly accumulating in aquatic environments and biota, with
potential adverse effects on individual organisms, communities and ecosystems. However …

Defining piscine endpoints: Towards score sheets for assessment of clinical signs in fish research

L Andersen, A Rønneseth, MD Powell… - Laboratory …, 2023 - journals.sagepub.com
The seminar 'Severity and humane endpoints in fish research'organized by the University of
Bergen, the Industrial and Aquatic Laboratory, together with Fondazione Guido Bernadini …

Weight of evidence tools in the prediction of acute fish toxicity

SE Belanger, AD Lillicrap, SJ Moe… - Integrated …, 2023 - Wiley Online Library
Acute fish toxicity (AFT) is a key endpoint in nearly all regulatory implementations of
environmental hazard assessments of chemicals globally. Although it is an early tier assay …