Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

The exploitation of CRISPR-Cas systems especially CRISPR-Cas9 has led to radical
advances in genome editing, gene activation, gene repression, protein imaging, and …

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …

The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome, caused by
genetic mutations that principally affect telomere biology. Approximately 35% of cases …

In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the
Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show …

RNA stability and quality control are integral parts of gene expression regulation. A key
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …

Premature transcription termination yields a wealth of unadenylated (pA−) RNA. Although
this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex …

The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation,
transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its …

Extracellular vesicles (EVs) are vesicle-like bodies with a double membrane structure that
are released from the cell membrane or secreted by cells into the extracellular environment …