The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …

Granulocyte-monocyte progenitors (GMPs) have been previously defined for their potential
to generate various myeloid progenies such as neutrophils and monocytes. Although …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5+ stem cells at the bottoms of …

Stem cell fate is influenced by specialized microenvironments that remain poorly defined in
mammals,,. To explore the possibility that haematopoietic stem cells derive regulatory …

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell
(CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct …

Abstract Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in
familial conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the …

The Notch1 receptor is presented at the cell membrane as a heterodimer after constitutive
processing by a furin-like convertase. Ligand binding induces the proteolytic release of …

In bone marrow, hematopoiesis is thought to depend on special microenvironments known
as niches that maintain blood cells. However, the identity of niches and interaction of blood …

One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a
niche that helps promote self-renewal of cancer stem-like cells (CSLC). However, the …