During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Collective cell migration requires maintenance of adhesive contacts between adjacent cells,
coordination of polarized cell protrusions, and generation of propulsive traction forces. We …

Cell–cell and cell–extracellular-matrix (cell–ECM) adhesions have much in common,
including shared cytoskeletal linkages, signaling molecules and adaptor proteins that serve …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

MUC1 is a transmembrane mucin that is often overexpressed in metastatic cancers and
often used as a diagnostic marker for metastatic progression. The extracellular domain of …

Intermediate filaments (IFs) are assembled from a diverse group of evolutionarily conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Abstract Background Keratins (KRTs) are intermediate filament proteins that interact with
multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an …