Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

To optimally penetrate biological hydrogels such as mucus and the tumor interstitial matrix,
nanoparticles (NPs) require physicochemical properties that would typically preclude …

This book presents a comprehensive overview of microrheology, emphasizing the
underlying theory, practical aspects of its implementation, and current applications to …

Nanoparticles larger than the reported mesh-pore size range (10–200 nm) in mucus have
been thought to be much too large to undergo rapid diffusional transport through mucus …

In microrheology, the local and bulk mechanical properties of a complex fluid are extracted
from the motion of probe particles embedded within it. In passive microrheology, particles …

Mucus linings serve as the body's first line of defense at exposed surfaces of the eye and
respiratory, gastrointestinal, and cervicovaginal tracts. The high viscoelasticity and …

Particle tracking techniques are often used to assess the local mechanical properties of cells
and biological fluids. The extracted trajectories are exploited to compute the mean-squared …

Intravitreal injection of biodegradable nanoparticles (NP) holds promise for gene therapy
and drug delivery to the back of the eye. In some cases, including gene therapy, NP need to …

The mechanisms by which mucus helps prevent viruses from infecting mucosal surfaces are
not well understood. We engineered non-mucoadhesive nanoparticles of various sizes and …