Introduction: Although significant progress has been made in high-throughput screening of
absorption, distribution, metabolism and excretion, and toxicity (ADME-Tox) properties in …

Drug discovery and development are aimed at identifying new chemical molecular entities
(NCEs) with desirable pharmacokinetic profiles for high therapeutic efficacy. The plasma …

Bisphenol A (BPA) is a chemical used in numerous industrial applications. Due to its well
ascertained toxicity as endocrine disruptor, industries have started to replace it with other …

Background Volume of distribution is an important pharmacokinetic property that indicates
the extent of a drug's distribution in the body tissues. This paper addresses the problem of …

The search for novel anticancer agents with higher selectivity and lower toxicity remains a
priority. This work aimed to design more potent and selective anticancer molecules among …

Abstract A series of 3, 4-dihydropyrimidin-2-(1H)-thiones (1–22) was synthesized through
the Biginelli reaction in order to find novel anticancer drug candidates based on the structure …

Abstract Five parabens (PBs) ie, Methylparaben (MP), Ethylparaben (EP), Isopropylparaben
(iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound ie, para …

Abstract A Quantitative Structure Activity Relationship (QSAR) model was developed in
order to predict the adipose/blood partition coefficient of environmental chemical …

Colour, an art term, is an important formal element that can influence our changing feelings,
and colour matching has a very important place in art. Colour is an important artistic …

The interactions between human serum albumin (HSA) and α 1-acid glycoprotein (AGP), the
main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals …