Deposition of inhaled particles in the lungs
AF Tena, PC Clarà - Archivos de Bronconeumología (English Edition), 2012 - Elsevier
Inhaled medication is the first-line treatment of diseases such as asthma or chronic
obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited …
obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited …
In silico models of aerosol delivery to the respiratory tract—development and applications
PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …
In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals
Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …
the past few decades because this route of administration offers multiple advantages over …
Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model
A basic analysis of inhaled multicomponent droplet-vapor interaction and subsequent
aerosol deposition is very important for the understanding of natural phenomena as well as …
aerosol deposition is very important for the understanding of natural phenomena as well as …
Delivery technologies for orally inhaled products: an update
Orally inhaled products have well-known benefits. They allow for effective local
administration of many drugs for the treatment of pulmonary disease, and they allow for …
administration of many drugs for the treatment of pulmonary disease, and they allow for …
Numerical model to characterize the size increase of combination drug and hygroscopic excipient nanoparticle aerosols
P Worth Longest, M Hindle - Aerosol Science and Technology, 2011 - Taylor & Francis
Enhanced excipient growth (EEG) is a newly proposed respiratory delivery strategy in which
submicrometer or nanometer particles composed of a drug and hygroscopic excipient are …
submicrometer or nanometer particles composed of a drug and hygroscopic excipient are …
Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract
Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways
The objective of this study was to evaluate the delivery of inhaled pharmaceutical aerosols
using an enhanced condensational growth (ECG) approach in an airway model extending …
using an enhanced condensational growth (ECG) approach in an airway model extending …
Targeting aerosol deposition to and within the lung airways using excipient enhanced growth
Background: Previous studies have characterized the size increase of combination
submicrometer particles composed of a drug and hygroscopic excipient when exposed to …
submicrometer particles composed of a drug and hygroscopic excipient when exposed to …
Influence of weather and seasonal variations in temperature and humidity on supersaturation and enhanced deposition of submicron aerosols in the human …
A Ishmatov - Atmospheric Environment, 2020 - Elsevier
In this review, all available data on the effects of supersaturation in human airways were
summarized and analysed, and the most critical parameters identified. The analysis shows …
summarized and analysed, and the most critical parameters identified. The analysis shows …