Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …

Introduction For the past two decades, virtual screening (VS) has been an efficient hit finding
approach for drug discovery. Today, billions of commercially accessible compounds are …

Blocking the immunosuppressive function of T-cell immunoglobulin mucin-3 (TIM-3) is an
established therapeutic strategy to maximize the efficacy of immune checkpoint inhibitors for …

Compared to small molecules and antibodies, cyclic peptides exhibit unique biochemical
and therapeutic attributes in the realm of pharmaceutical applications. The interaction …

Immune checkpoint inhibitors (ICIs) are used to relieve and refuel anti-tumor immunity by
blocking the interaction, transcription, and translation of co-inhibitory immune checkpoints or …

The revolutionary progress in cancer immunotherapy, particularly the advent of immune
checkpoint inhibitors, marks a significant milestone in the fight against malignancies …

Herein, we performed a virtual screening study to discover new scaffolds for small molecule-
based ligands of the immune checkpoint lymphocyte-activation gene 3 (LAG-3). Molecular …