INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. ALL arises
from the malignant transformation of progenitor B-and T-cells in the bone marrow into …

Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

Chromatin modifications, such as cytosine methylation of DNA, play a significant role in
mediating gene expression in plants, which affects growth, development, and cell …

Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and
incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and …

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that
comprises the accumulation of malignant T-cells. Despite current therapies, failure to …

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular
subtypes, and while transcriptional and DNA methylation profiling has been extensively …

Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are
emerging as intracellular Ca2+ stores that govern multiple cellular processes. Dys …

Biomarkers are biological molecules found in body fluids or tissues, which can be
considered as indications of a normal or abnormal process, or of a condition or disease …